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KMID : 0358619940280020159
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Korean Journal of Physiology
1994 Volume.28 No. 2 p.159 ~ p.167
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Role of Exchange in the Control of Contractility in Rabbit Basilar Arterial Smooth Muscle
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Kim Eui-Yong
Han Jin
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Abstract
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The contraction of rabbit basilar artery was examined as a function of changes in the electrochemical gradient in order to determine the contribution of exchange to the modulation of contractility. Ouabain or Tyrode solution caused an increase in tonic tension even in the presence of a channel blocker and an blocker . After treatment with ouabain , contractions were augmented by reduction of external concentration. The longer the treatment with ouabain was, the larger the amplitude of contracture was. contracture wag induced by either substitution of equimolar Tris for or substitution of equimolar . The competition between for the exchange carrier would exist, because it was observed that contractility was dependent on the electrochemical gradient or the extracellular concentration (2 mM, 4 mM). Ryanodine , the blocker of intracellular release from the sarcoplasmic reticulum, did not suppress the development of contracture. The contractile response to norepinephrine was augmented by reducing the extracellular concentration. The relaxation rate from caffeine-induced contraction was dependent on the extracellular concentration (0 mM, 140 mM). From the above results, it could be suggested that exchange can move either into or out of rabbit basilar arterial smooth muscle. entry or extrusion is dependent upon the electrochemical gradient. exchange plays a significant role in the regulation of contractility in rabbit basilar arterial smooth muscle.
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KEYWORD
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exchange, Rabbit basilar arterial smooth muscle, Contractility, electrochemical gradient
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